We use cookies to make this site work. We'd also like to set optional cookies so we can understand how the site is used and improve it. We will not set optional cookies unless you accept them. You can change your choice at any time from the Cookie settings link in the footer.
Strictly necessary cookies
These cookies are required for the site to work. They store your cookie preferences and keep your session secure. They are exempt from consent under PECR Regulation 6(4) because they are essential to deliver the service you have requested.
Optional cookies
Optional cookies help us understand how the site is used and provide additional features such as analytics, accessibility tools and translation. We will only set them if you accept.
The LIFE trial
The mechanisms underlying the antidepressant effects of physical activity (IRAS: 161223)
This study aims to conduct a randomised, controlled trial in approximately 250 participants suffering from depression, comparing aerobic exercise to a stretching/relaxation control condition. The trial will examine the impact of physical activity on a range of mental health and mechanistic factors
- Chief Investigator: Professor Jonathan Roiser
- Study Sponsor: University College London (UCL)
Patient participation
Participants will be randomised to eight weeks of either a) 45-minute aerobic exercise of moderate-to-vigorous activity three times per week or b) 45-minute non-aerobic stretching/guided relaxation three times per week. Both arms will be delivered by the same sports science research assistants.
Brief daily depression symptoms will be recorded using the Neureka smartphone app. Cognitive tests will be completed by participants online on “odd” weeks (week 1, week 3, week 5 and week 7), whilst symptom questionnaires will be completed online at alternate “even” weeks (week 2, week 4, week 6 and week 8).
Other trial activities include:
- measuring brain activity using functional magnetic resonance imaging (fMRI);
- providing blood and saliva samples at regular intervals to assess changes inimmune-metabolic markers; measuring physical activity continuously using accelerometers;
- and follow up in regards to cognition and symptoms.
Payments to participants for the assessments will be made at the standard UCL Psychology and Language Sciences rate at the time of consent, which is currently £9/hour.
Patient eligibility
Inclusion:
- Current depression diagnosis
- Aged 18 to 60
- Current physical activity level below 30 min moderate physical activity, once per week
Exclusion:
- Neurological or inflammatory disorders, or conditions for which intense physical activity would put an individual at risk
The research team will provide pre-made EMIS search file based on inclusion/exclusion criteria, and will conduct all eligibility checks directly with potential participants.
To express an interest in this study or find out information on other studies open to you, please contact us.